Adrenal function during topical oral corticosteroid treatment

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Adrenal function during topical oral corticosteroid treatment.

Plasma cortisol (hydrocortisone) levels were measured in 42 subjects before and during administration of topical oral corticosteroids. Topical administration of 0.3-0.4 mg. of betamethasone disodium phosphate daily caused partial suppression of adrenal function in 8 out of 10 subjects tested. The adrenal function remained normal in 14 patients treated with 10 mg. of hydrocortisone hemisuccinate...

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Symptomatic adrenal insufficiency during inhaled corticosteroid treatment.

Symptomatic adrenal insufficiency, presenting as hypoglycaemia or poor weight gain, may occur on withdrawal of corticosteroid treatment but has not previously been reported during inhaled corticosteroid treatment. This case series illustrates the occurrence of clinically significant adrenal insufficiency in asthmatic children while patients were on inhaled corticosteroid treatment and the unexp...

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Symptomatic adrenal insuYciency during inhaled corticosteroid treatment

Symptomatic adrenal insuYciency, presenting as hypoglycaemia or poor weight gain, may occur on withdrawal of corticosteroid treatment but has not previously been reported during inhaled corticosteroid treatment. This case series illustrates the occurence of clinically significant adrenal insuYciency in asthmatic children while patients were on inhaled corticosteroid treatment and the unexpected...

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Pituitary adrenal function during corticosteroid withdrawal in rheumatoid arthritis.

It has been known for many years that administration of corticosteroids can cause atrophy of the adrenal glands (Ingle and Kendall, 1937), and that the severity of the atrophy is proportional to the duration of administration (Salassa, Bennett, Keating, and Sprague, 1953; Bennett, 1954). Kilby, Bennett, and Sprague (1957) described degranulation of the basophil cells of the pituitary which also...

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Topical corticosteroid use during pregnancy.

QUESTION Some of my pregnant patients have been prescribed various potencies of topical corticosteroids. Do these carry the same fetal risks as systemic corticosteroids? ANSWER Pregnant women can be reassured that there is no apparent increased risk of adverse fetal effects when using topical corticosteroids during pregnancy, although some data do suggest fetal growth restriction with more po...

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ژورنال

عنوان ژورنال: BMJ

سال: 1969

ISSN: 0959-8138,1468-5833

DOI: 10.1136/bmj.4.5676.138